Protein Details: Glutamate receptor ionotropic;NMDA 2C
Protein ID
ICDB_Pro_0836
Protein Name
Glutamate receptor ionotropic;NMDA 2C
Gene Name
GRIN2C; NMDAR2C
Organism
Homo sapiens (Human)
Length
1233 amino acids
AlphaFoldDB
AF-Q14957-F1-model_v4.pdb
Function
Component of NMDA receptor complexes that function as heterotetrameric;ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit;glycine binding to the zeta subunit;plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current;long-term synaptic potentiation;and learning (By similarity).
Sequence
Ligand Binding
Binding Site
BINDING 509..511; /ligand="L-glutamate"; BINDING 511; /ligand="L-glutamate"; BINDING 516; /ligand="L-glutamate"; BINDING 687..688; /ligand="L-glutamate"; BINDING 729; /ligand="L-glutamate"
Disease
Rare Genetic Epilepsy and Neuronopathy;Distal Hereditary Motor;Autosomal Recessive 10
Location
Mainly expressed in brain with predominant expression is in the cerebellum;also present in the hippocampus;amygdala;caudate nucleus;corpus callosum;subthalamic nuclei and thalamus. Detected in the heart;skeletal muscle and pancreas.
DOI ID
10.1016/s0169-328x(96)00146-5; 10.1038/nature04689; 10.1101/gr.2596504; 10.1128/mcb.01044-10; 10.1016/j.neuron.2016.01.016; 10.1371/journal.pgen.1006536; 10.1038/tp.2011.52
RefSeq
NP_000826.2